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Herpes on the skin of acyclovir pills - foci of herpes can appear on any part of the skin of the face, which is usually associated with a violation of the integrity of the skin (scratches, cuts, abrasions). Typical localization - herpes on the cheeks and on the nose, earlobes, chin, forehead. The skin around the eyes can also be affected, but we have identified this type of lesion in a separate column.

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Relapses can be repeated 1 or 2 times a year, but sometimes much more often, which ultimately depends on the state of your immune system and nervous system. Depending on the extent of the skin lesion and the severity of the clinical manifestations, either an antiviral skin cream or a cream in combination with antiviral tablets may be prescribed. You can see a detailed overview of drugs for treatment at the end of the article.

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Herpes in the mouth (Fig. 10-11) - herpes of the tongue, gums and other parts of the oral mucosa is most common in children, rarely in adults. This disease is called herpetic stomatitis. After the bubbles on the mucous membrane burst, bright red erosions form in their place, which are quickly covered with a whitish-yellow fibrinous coating. Along the perimeter of the foci there is always a bright red corolla of inflamed mucous membrane.

In children, herpetic stomatitis is often accompanied by gingivitis. In this case (in addition to order acyclovir pills vesicles and erosions in some part of the oral mucosa), you can see bright red inflamed gums.

  • Common symptoms of herpes - a primary herpes infection can occur with symptoms similar to the flu or SARS (fever, muscle pain, and even enlargement of the submandibular lymph nodes).
  • But such acute symptoms are observed only in 10% of all cases. With repeated outbreaks, the general condition of the body is usually not disturbed.
  • But in order for the treatment of herpes to be as effective as possible, you must strictly follow the following rules.
  • Cream or ointment for herpes with acyclovir should be applied to the lesion and the skin around it - at least 5 times a day (but preferably every 2 hours while you are awake).
  • The duration of therapy is usually 5 days, but in the case of severe herpetic lesions, the duration of use can be increased to 7-10 days. It should be noted that the form in the form of a cream is more preferable to the ointment, because. from the ointment substance, the active substances penetrate the skin much worse.
  • It is worth paying attention to the composition, for example, the effective concentration of acyclovir is exactly 5% (although in pharmacies you can also find products with a 3% concentration). In addition, the composition should preferably contain propylene glycol and / or cetomacrogol, which increase the penetration of acyclovir molecules through the surface layers of the skin.

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To date, the best topical preparation for herpes is Zovirax Duo-Active cream, which contains a combination of 5% acyclovir and 1% hydrocortisone. Acyclovir blocks the reproduction of acyclovir online, and the guideRocortisone reduces inflammation and swelling. At the same time, if the use of the cream begins even before the appearance of herpetic vesicles, then hydrocortisone sometimes allows you to generally prevent their formation. But if bubbles form, then their number and size will be smaller, which in itself will significantly accelerate healing.

  • This is important because by itself, acyclovir penetrates poorly through the epidermis of the skin and the resulting crusts.
  • Disadvantages of drugs based on acyclovir - acyclovir is an outdated drug, but in principle it works well in most patients (with some exceptions).
  • For example, in patients with good immunity, resistance of the herpes virus to acyclovir occurs - on average, only 3% of cases, which is quite small.

However, immunocompromised patients + frequent courses of acyclovir in the past are a problem - in such groups of patients, resistance to acyclovir can already be observed from 10 to 27% of cases.

  • In addition, acyclovir molecules have a very low affinity for the herpes virus, which means that zovirax usually simply does not find a certain percentage of viral particles in cells (for example, drugs based on penciclovir / famciclovir have much higher tropism in the virus).
  • In addition, acyclovir molecules tend to penetrate poorly through the skin, as well as through the resulting crusts (to the site of virus reproduction).
  • In order to somehow reduce this problem, some manufacturers add propylene glycol and cetomacrogol to the composition of external agents with zovirax.

We have already said above that immunocompromised patients often develop resistance of the herpes virus to acyclovir. What to do with such patients? International recommendations in this case indicate the need to use courses of famciclovir in tablets - these are drugs such as Favirox or Famvir. Tablet preparations based on valacyclovir (if resistance to acyclovir is suspected) - it does not make sense to use, because. Valaciclovir is the precursor to acyclovir. The latter means that if there is resistance to acyclovir, there will be resistance to valaciclovir.